Angels tells the story of two born losers. Jamie has ditched her husband and is running away with her two baby girls. Bill is dreaming of making it big in a life of crime. They meet on a Greyhound bus and decide to team up.

So begins a stunning, tragic odyssey through the dark underbelly of America - the bars, bus stations, mental wards and prisons that play host to Jamie and Bill as they find themselves trapped in a downward spiral though rape, alcohol, drugs and crime, to madness and death.